Pregnenolone Rescues Schizophrenia-Like Behavior in Dopamine Transporter Knockout Mice
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منابع مشابه
Pregnenolone Rescues Schizophrenia-Like Behavior in Dopamine Transporter Knockout Mice
Pregnenolone belongs to a class of endogenous neurosteroids in the central nervous system (CNS), which has been suggested to enhance cognitive functions through GABA(A) receptor signaling by its metabolites. It has been shown that the level of pregnenolone is altered in certain brain areas of schizophrenic patients, and clozapine enhances pregnenolone in the CNS in rats, suggesting that pregnen...
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OF TALK The monoaminergic neurotransmitter dopamine (DA) has been implicated in multiple brain disorders including schizophrenia, attention deficit hyperactivity disorder (ADHD), addiction and Parkinson's disease. Dopamine transporter (DAT) is a major regulator of both the intensity of extracellular dopamine (DA) signaling and presynaptic neuronal homeostasis. By deleting the gene encoding the ...
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Mice lacking the dopamine transporter (DAT-/-) are characterized by high extracellular dopamine levels and spontaneous hyperlocomotion. We performed a detailed analysis of the behavioral phenotype of DAT-/mice in order to identify other behavioral impairments associated with the hyperdopaminergic tone of these mutant mice. In particular, we investigated locomotor activity, exploration, social a...
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Mice lacking the dopamine transporter (DAT-/-) are characterized by high extracellular dopamine levels and spontaneous hyperlocomotion. We performed a detailed analysis of the behavioural phenotype of DAT-/- mice in order to identify other behavioural impairments associated with the hyperdopaminergic tone of these mutant mice. In particular, we investigated locomotor activity, exploration, and ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0051455